We seek to unravel how metalloenzymes convert small molecules using inorganic chemistry. Our approach is to develop, investigate, and exploit unusual structure-function motifs that are found in nature. For example, Fe-Fe hydrogenases may utilize metal-metal bonding for activating hydrogen. By preparing model coordination complexes featuring reactive metal-metal bonds, we can extract a detailed picture of their physical and electronic structures that may elucidate the underpinnings of their function. We can then apply this understanding towards new systems that improve on the natural counterparts in activity, selectivity, and substrate scope.
